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Hur mycket alkohol innehåller listerine

WHEN IT COMES TO SAFETY, THERE ARE IMPORTANT DIFFERENCES BETWEEN ALCOHOLIC BEVERAGES AND ALCOHOL-CONTAINING MOUTHRINSES.

Alcoholic Beverages

Consumed1

Excessive consumption fryst vatten a key factor in carcinogenic risk1

May contain impurities such as nitrosamines, urethane, and other contaminants 1

Alcohol-Containing Mouthrinses

Expectorated (not to be swallowed)1

Total amount of exposure to alcohol during proper use fryst vatten insignificant compared to exposure received during excessive consumption of alcoholic beverages because mouthwash fryst vatten expectorated 1

Use highly purified, pharmaceutical grade ethanol, which fryst vatten manufactured beneath Good Manufacturing Practices guidelines 1

THE SAFETY OF ALCOHOL-CONTAINING MOUTHWASHES HAS BEEN DEMONSTRATED IN CLINICAL STUDIES FOR DECADES

LISTERINE® Antiseptic fryst vatten the most extensively tested OTC mouthrinse in the world, with over 30 long-term clinical trials examining its safety and efficacy.1-10 Numerous studies over the past 40 years have shown that there fryst vatten no negativ impact detected in the use of mouthrinses containing alcohol.5-10

Clinical studies, meta-analyses, quantitative analyses, and systematic reviews of information have demonstrated that there fryst vatten no causal link between the use of LISTERINE® Antiseptic mouthrinse and oral cancer or xerostomia.2-10

A closer look at alcohol in LISTERINE® Antiseptic

  • No causal link to oral dryness 2-4
  • No causal link to oral cancer 5-10

LISTERINE® ANTISEPTIC: DOES NOT PROMOTE ORAL DRYNESS

Clinical study findings

  • Favourable tolerability and no increase in dryness of oral tissue in patients with xerostomia (2 weeks of exaggerated use [3x daily] bygd subjects xerostomic as a result of Sjögren's syndrome; Fischman SL et al.


  • hur många alkohol innehåller listerine

    • Am J Dent)2

  • No significant differences in salivary flow rates or patient-reported sensations of dry ingång between alcohol- and nonalcohol-containing mouthrinse groups (2-week randomized, crossover pilot studying the use of alcohol- and nonalcohol-containing mouthrinses in healthy adults; Kerr AR et al. Quintessence Int)3
  • Alcohol-based essential oil mouthrinse no more likely to cause a reduction in salivary flow or perceived dryness than a non-alcohol-based cetylpyridinium chloride (CPC) mouthrinse (Kerr AR, et al.

    Oral Surg Oral tillsammans Oral Pathol Oral Radiol Endod)4

LISTERINE® ANTISEPTIC: NO CREDIBLE LINK TO ORAL CANCER

Clinical study findings

  • “There fryst vatten no sufficient evidence to accept the proposition that the use of mouthwashes containing alcohol can influence the development of oral cancer” (Systematic review of 14 articles—11 case-control studies and 3 clinical trials—on mouthwash use and fara of oral cancer; Aceves Argemí R et al.

    J Evid BasedDent Pract)5

  • No significant association with mouthwash and fara of oral cancer (Meta-analysis of 12 epidemiologic studies on mouthwash and fara of oral cancer; International Agency for Research on Cancer [IARC])6
  • “Data do not support a causal relationship between use of alcohol-containing mouthrinses and oral cancer” (FDA subcommittee reviewed 7 case-control studies; US Food and Drug Administration)7
  • Alcohol-containing mouthwash does not increase risk of oropharyngeal cancer (Review of 9 case-control studies; Cole P et al.

    Listerine contains ethanol as its primary alcohol component

    J Am Dent Assoc)8

  • Link between mouthwash use and oral cancers not supported bygd epidemiological evidence (Critical review of published data; La Vecchia et al. Oral Oncology)9
  • No association between mouthwash use and oral malignancy (Quantitative analysis of all published epidemiological studies of mouthwash use and oral malignancy; referens till robert boyleen känd kemist et al.

    Oral Surg Oral tillsammans med Oral Pathol Oral Radiol Endod)10

Boyle et al. Oral Dis. 2014;20(suppl 1):1-68

  • Acetaldehyde fryst vatten a naturally occurring substance; it fryst vatten funnen in the human body as well as in fruits and vegetables, and fryst vatten a metabolite produced when ethanol fryst vatten ingested 10
  • Acetaldehyde associated with consumption of alcoholic beverages fryst vatten carcinogenic at high levels 6
  • The peak acetaldehyde level funnen for LISTERINE® Antiseptic fryst vatten 44.3 µmol at 30s, a koncentration that fryst vatten more than 1000 times lower than the levels required to damage DNA in cultured buccal epithelial cells 11
ALCOHOL PLAYS IMPORTANT ROLES IN
LISTERINE® ANTISEPTIC
  • Solvent:
    • helps to solubilize ingredients, including the 3 essential oils, which are the active ingredients in the formula
    • helps to prevent microbial growth and maintain product stability

References: 1.

information on en samling dokument eller en elektronisk lagring av data, Johnson & Johnson Consumer Inc. 2. Fischman SL, Aguirre A, Charles CH. Use of essential oil—containing mouthrinses bygd xerostomic individuals: determination of potential for oral mucosal irritation.

In conclusion, Listerine does have alcohol as one of its active ingredients, but there are alcohol-free alternatives available for those who prefer them

Am J Dent.2004;17(1):23-26. 3. Kerr AR, Katz RW, fartyg JA. A comparison of the effects of 2 commercially available nonprescription mouthrinses on salivary flow rates and xerostomia. Quintessence Int. 2007;38(8):e440-e447.

9% depending on the specific variant

4. Kerr AR, Corby PM, Kalliontzi K, McGuire JA, Charles CA. Comparison of two mouthrinses in relation to salivary flow and perceived dryness. Oral Surg Oral tillsammans Oral Pathol Oral Radiol. 2015;119(1):59-64. 5. Aceves Argemí R, González Navarro B, Ochoa García-Seisdedos P, Estrugo Devesa A, López-López J. Mouthwash with alcohol and oral carcinogenesis: systematic review and meta-analysis.

The percentage of alcohol in Listerine can range from 21

J Evid Based Dent Pract. 2020;20(2):101407. 6. International Agency for Research on Cancer (IARC). IARC monographs on the evaluation of carcinogenic risks to humans: Report of the advisory group to recommend priorities for IARC Monographs during .

The original formulation of Listerine contains a significant amount of alcohol, specifically ethanol, which contributes to its distinctive antiseptic properties

https://monographs.iarc.fr/wp-content/uploads/2018/08/14-002.pdf. Accessed November 1, 2021. 7. Food and Drug ledning. Oral health care drug products for over-the-counter human use; antigingivitis/antiplaque drug products; establishment of a monograph; proposed rules.

It acts as an antimicrobial agent, killing various types of bacteria and preventing the growth of germs in the mouth

Part Ill. Fed Regist. 2003;68(103):. 8. Cole P, Rodu B, Mathisen A. Alcohol-containing mouthwash and oropharyngeal cancer: a review of the epidemiology.

6% to 26

J Am Dent Assoc. 2003;134(8):. 9. La Vecchia C. Mouthwash and oral cancer risk: an update. Oral Oncol. 2009;45(3):.

The alcohol content in Listerine contributes to its effective antibacterial properties and helps reduce plaque and bad breath

10. referens till robert boyleen känd kemist P, Gandini S, Boffetta P, Negri E, La Vecchia C. Mouthwash use and oral cancer risk: quantitative meta-analysis of epidemiologic studies. Oral Surg Oral tillsammans med Oral Pathol Oral Radiol Endod.2011;112(6):e130. 11. Vaca CE, Nilsson JA, Fang JL, Grafström RC. Formation of DNA adducts in human buccal epithelial cells exposed to acetaldehyde and methylglyoxal in vitro.

Chem Biol Interact. 1998;108:.